Producción continua de ésteres metílicos por extracción reactiva, empleando un módulo de membrana de fibra hueca

Una de las principales tecnologías estudiadas para la producción de biodiésel por procesos intensificados es el uso de membranas. Diversos investigadores han realizado evaluaciones de su desempeño, especialmente para la retención del glicerol libre y ligado, en las etapas de separación y purificación de los productos, así como para la reacción/separación simultáneas y como soporte de catalizadores heterogéneos. En este trabajo se presentan los resultados experimentales de la evaluación de un proceso continuo, para un reactor de película líquida descendente (RPLD), acoplado a un módulo con membranas de fibra hueca de polietersulfona (PES). En este reactor la separación del glicerol ocurre simultáneamente con la reacción, mediante el uso de las membranas. Esta técnica de reacción/separación, tiene como objetivo desplazar el equilibrio químico, con el fin de incrementar la conversión y el rendimiento hacia ésteres metílicos comparados con el RPLD sin membranas. El uso del RPLD acoplado al módulo con membranas, no incrementó la conversión de aceite ni el rendimiento en comparación con el RPLD sin membranas. Sin embargo, la composición másica de la corriente de permeado, confirma la capacidad que tiene esta configuración para remover la mezcla glicerol-metanol. Este tipo de reactor presenta entonces, un gran potencial para su estudio en intensificación de procesos para producción de biodiésel.Abstract One of the main technologies studied for the production of biodiesel by intensified processes is the use of membranes. Several investigators have evaluated their performance, especially for retention of free and bound glycerol, in the steps of separation and purification of products as well as for the simultaneous reaction and separation-like support of heterogeneous catalysts. This work presents results of the experimental evaluation of a continuous process for biodiesel production in a falling film reactor (FFR) coupled to polyethersulfone (PES) hollow fiber membranes (HFM). In that reactor glycerol separation takes place simultaneously with the reaction, through the hollow fiber membranes. This reaction–separation technique seeks shift the reaction equilibrium to the product side, increasing conversion of oil and yield to methyl esters compared to the FFR without membranes. FFR coupled to HFM modulus, did not increase the conversion of oil or yield, compared to FFR without membranes. However, the mass composition of the permeate stream confirms the capacity of this configuration to remove the mixture glycerol-methanol selectively. In conclusion, this kind of reactor presents a great potential to study process intensification with membranes in biodiesel production.Maestrí

DFT-s-OFDM for sub-THz Transmission -- Tracking and Compensation of Phase Noise

For future wireless communication technologies, an increase in capabilities such as throughput is strongly expected. Transmission in the sub-THz bands (>90 GHz) seems to be the potential solution to meet the ever-increasing capacity demands due to the large unexploited bandwidth. Oscillators used at these frequencies generate phase noise that induces critical distortions in the signal that must be addressed. The correlated nature of PN makes it difficult to overcome. Nowadays, there is a growing interest in considering the extension of multicarrier based waveforms of the 5G new radio for transmissions in the sub-THz bands. In this paper, we introduce a new algorithm called the interpolation filter (IF), which efficiently estimates and compensates PN effects on DFT-s-OFDM systems. Specifically, it is based on the use of stochastic properties of the PN and is compatible with the 3GPP phase tracking reference signal scheme. We highlight a performance improvement over known techniques when using high-order modulation.Comment: Paper accepted and will be presented at the IEEE CCNC 2023 Conference that will be held in Las Vegas from January 8th to 11th, 202

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Five insights from the Global Burden of Disease Study 2019

The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2•72 (95% uncertainty interval [UI] 2•66–2•79) in 2000 to 2•31 (2•17–2•46) in 2019. Global annual livebirths increased from 134•5 million (131•5–137•8) in 2000 to a peak of 139•6 million (133•0–146•9) in 2016. Global livebirths then declined to 135•3 million (127•2–144•1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2•1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27•1% (95% UI 26•4–27•8) of global livebirths. Global life expectancy at birth increased from 67•2 years (95% UI 66•8–67•6) in 2000 to 73•5 years (72•8–74•3) in 2019. The total number of deaths increased from 50•7 million (49•5–51•9) in 2000 to 56•5 million (53•7–59•2) in 2019. Under-5 deaths declined from 9•6 million (9•1–10•3) in 2000 to 5•0 million (4•3–6•0) in 2019. Global population increased by 25•7%, from 6•2 billion (6•0–6•3) in 2000 to 7•7 billion (7•5–8•0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58•6 years (56•1–60•8) in 2000 to 63•5 years (60•8–66•1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation: Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Global burden of 87 risk factors in 204 countries and territories, 1990�2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods: GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk�outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk�outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk�outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each age-sex-location-year. (6) PAFs and attributable burden for combinations of risk factors were estimated taking into account mediation of different risk factors through other risk factors. Across all six analytical steps, 30 652 distinct data sources were used in the analysis. Uncertainty in each step of the analysis was propagated into the final estimates of attributable burden. Exposure levels for dichotomous, polytomous, and continuous risk factors were summarised with use of the summary exposure value to facilitate comparisons over time, across location, and across risks. Because the entire time series from 1990 to 2019 has been re-estimated with use of consistent data and methods, these results supersede previously published GBD estimates of attributable burden. Findings: The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure. Global declines also occurred for tobacco smoking and lead exposure. The largest increases in risk exposure were for ambient particulate matter pollution, drug use, high fasting plasma glucose, and high body-mass index. In 2019, the leading Level 2 risk factor globally for attributable deaths was high systolic blood pressure, which accounted for 10·8 million (95 uncertainty interval UI 9·51�12·1) deaths (19·2% 16·9�21·3 of all deaths in 2019), followed by tobacco (smoked, second-hand, and chewing), which accounted for 8·71 million (8·12�9·31) deaths (15·4% 14·6�16·2 of all deaths in 2019). The leading Level 2 risk factor for attributable DALYs globally in 2019 was child and maternal malnutrition, which largely affects health in the youngest age groups and accounted for 295 million (253�350) DALYs (11·6% 10·3�13·1 of all global DALYs that year). The risk factor burden varied considerably in 2019 between age groups and locations. Among children aged 0�9 years, the three leading detailed risk factors for attributable DALYs were all related to malnutrition. Iron deficiency was the leading risk factor for those aged 10�24 years, alcohol use for those aged 25�49 years, and high systolic blood pressure for those aged 50�74 years and 75 years and older. Interpretation: Overall, the record for reducing exposure to harmful risks over the past three decades is poor. Success with reducing smoking and lead exposure through regulatory policy might point the way for a stronger role for public policy on other risks in addition to continued efforts to provide information on risk factor harm to the general public. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Wiener interpolation filter for phase noise estimation in sub-THz transmission

International audienceHigh frequency transmissions above 90 GHz, as planned for the future generation of communication technology called 6G, have to deal with oscillator-induced phase noise. This phase noise deteriorates the system performance and then, signal processing techniques are mandatory to counteract its effects. In this paper, we describe and analyze a phase noise estimation algorithm based on an Wiener interpolation filter. The proposed technique is waveform agnostic and can be applied either to 5G-NR mutlicarrier waveforms such as orthogonal frequency division multiplexing (OFDM) and discrete Fourier transform spread OFDM (DFT-s-OFDM), or to single carrier systems. In this study, we highlight the feasibility of this algorithm in practical scenarios by providing both a theoretical analysis and a performance evaluation

Analyse des effets du bruit de phase Gaussien sur un signal DFT-s-OFDM

International audienceIn this paper, we present the effects of a Gaussian phase noise model on a DFT-s-OFDM system. We show that thepresence of this phase noise induces two interference terms which are: (i) the subcarrier phase error (SPE) and (ii) the intercarrier interference (ICI). Additionally, we notice that the SPE can be considered as a phase shift where the phase follows an uncorrelated Gaussian random process. Otherwise, the ICI cannot be considered as an uncorrelated complex gaussian random process. The uncorrelated nature of the phase noise makes difficult to estimate it. In order to improve the system performance, we propose a novel detection criterion based on stochastic properties of the SPE and ICI. We demonstrate that the detector achieves better performance than a detector based on the Euclidean distance.Dans cet article, nous présentons les effets du bruit de phase Gaussien sur un système DFT-s-OFDM. La présence de ce dernier induit l'apparition de deux termes d'interférences qui sont : (i) l'erreur de phase par porteuse (SPE) et (ii) l'interférence entre porteuse (ICI). De plus, nous montrons que le SPE peut être réduit à un dephasage tel que la phase suit une distribution Gaussienne non corrélée. Par contre l'ICI quant à elle, ne suit pas une distribution Gaussienne complexe non corrélée. La nature non corrélée du bruit de phase rend impossible l'estimation de ce dernier. Afin d'améliorer les performances du système, nous proposons un détecteur basé sur les propriétés stochastiques du SPE et de l'ICI. Les performances du détecteur proposé sont meilleures comparées à celles du récepteur basé sur la distance Euclidienne

Compensation du bruit de phase et évaluation des performances d'un émetteur-récepteur CMOS à 140 GHz

International audience– In this work, we show the performance of a phase noise estimation and compensation algorithm validated on laboratory phase noise measurements. We introduce an easily realizable concept and show how to estimate some parameters required for theimplementation of this algorithm. We present the link budget of a CMOS wireless communication system operating in the sub-THz bands, more precisely at 140 GHz.Dans ce travail, nous montrons les performances d'un algorithme d'estimation et de compensation du bruit de phase validé sur des mesures de laboratoire. Nous introduisons un concept facilement réalisable et nous montrons comment estimer certains paramètres requis pour l'implémentation de cet algorithme. Nous présentons le bilan de liaison d'un système de communications sans-fils CMOS opérant dans les bandes sub-THz, plus précisément à 140 GHz